What Makes the Harderian Gland Transcriptome Different From Other Chicken Immune Tissues? A Gene Expression Comparative Analysis

What Makes the Harderian Gland Transcriptome Different From Other Chicken Immune Tissues? A Gene Expression Comparative Analysis

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The Harderian spidertattooz.com gland is a sparsely characterized immune tissue known to play an important role in local immunity.The function of the Harderian gland, however, is not clearly defined.Measuring the expression of all genes using RNA-seq enables the identification of genes, pathways, or networks of interest.

Our relative RNA-seq expression analysis compared the chicken Harderian gland transcriptome to other important primary and secondary immune tissues including the bursa of Fabricius, thymus, and spleen of non-challenged birds.A total of 2,386 transcripts were identified as highly expressed in the Harderian gland.Gene set enrichment showed transpharm online shopping the importance of G-protein coupled receptor signaling and several immune pathways.

Among the genes highly expressed in the Harderian gland were 48 miRNAs, a category of genetic elements involved in regulation of gene expression.Several identified miRNAs have immune related functions.This analysis gives insight to the unique immune processes inherent in the Harderian gland.